Bio IT World Expo 2016  
Bio IT World Expo 2016

Track 4 - April 5 – 7, 2016

Cloud Computing 

Applying Cloud for Next-Generation Computing

Life scientists agree that the shift to cloud is both necessary and practical. Adoption has been greater than anyone expected and users continue to expand applications. Track 4 explores the rapid growth and progressive maturation of cloud as well as evolving provider and user experiences.

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Tuesday, April 5

7:00 am Workshop Registration and Morning Coffee

8:00 – 11:30 Recommended Morning Pre-Conference Workshops*
Security Considerations for Virtual Research

12:30 – 4:00 pm Recommended Afternoon Pre-Conference Workshops*
Growth Strategy: Leveraging Cloud Scalability to Enable Rapid Growth and Change

* Separate registration required

2:00 – 6:00 Main Conference Registration


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5:00 – 7:00 Welcome Reception in the Exhibit Hall with Poster Viewing

Wednesday, April 6

7:00 am Registration Open and Morning Coffee


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9:00 Benjamin Franklin Awards and Laureate Presentation

9:30 Best Practices Awards Program

9:45 Coffee Break in the Exhibit Hall with Poster Viewing


10:50 Chairperson’s Opening Remarks

11:00 Building the Bionic Cloud

Michaela Iorga, Ph.D., Senior Security Technical Lead for Cloud Computing; Co-Chair, NIST Cloud Security Working Group; Co-Chair, NIST Cloud Forensic Science Working Group, National Institute of Standards and Technology

When coupling the continuously growing and changing landscape of advance persistent threats with the explosion of “pervasive computing” or “ambient intelligence” founded by the hyperconnectivity of “everyware”, we reach a technical inflection point which calls for innovative solutions to support the further development of a strong, secure backbone of the Internet of Things (IoT) – a bionic cloud.

11:30 Adopting Public Cloud at Enterprise Scale: Public IaaS at AstraZeneca

Don Barber, Infrastructure Architect, Enterprise Computing, IT Infrastructure & Operations, AstraZeneca

Public cloud adoption at scale requires significant rethinking of enterprise systems, processes and culture. This talk outlines how AstraZeneca IT has made this journey to offer public cloud as an enterprise service by tackling challenges with provisioning, management, security and qualification. Subject material will range broadly from technical issues to policy challenges and workforce education needs, concluding with a few predictions about the future.

12:00 pm Talk Title to be Announced

Stephen Worth, Director, Engineering, EMC

Google Cloud Platform12:15 Presentation to be Announced

12:30 Session Break

12:40 Luncheon Presentation I: Making Cloud R&D Electronic Laboratory Environments a Reality

John Conway, Global Director, Strategy and Technology, Research and Development, LabAnswer

The drivers behind moving to Cloud-based, enterprise class, scientific software applications are substantial, and the trend is rapidly gaining momentum. LabAnswer will showcase examples and discuss the practical considerations of deploying electronic laboratory environments (ELE) via the Cloud, including Electronic Laboratory Notebooks, LIMS, etc. Capabilities and functionality topics to be addressed include Data Governance, Entity Registration, Request/Sample/Inventory Management, and Data Aggregation & Analytics.

1:10 Luncheon Presentation II (Sponsorship Opportunity Available)

1:40 Session Break

1:50 Chairperson’s Remarks

Tom Johnson, Senior Director & Product Manager, Pharma and Life Sciences Services, Exostar

1:55 Cloud Computing in a GxP Environment

Krista Woodley, Director, Digital Quality and Risk Management, Biogen

We discuss the regulatory expectations and associated challenges with moving to cloud-based solutions (SaaS, IaaS, PaaS). Discussion points include requirements for vendor oversight, validation and maintenance of cloud-based solutions.

2:25 Case Study: How Merck Is Leveraging Information Security to Enable & Accelerate Clinical Trials

Andrew K. Porter, Director, Enterprise Architecture, IT Planning & Innovation, Merck & Co.

Bringing data, applications and people together for clinical trials takes too long, costs too much and leaves security gaps that threaten intellectual property and regulatory compliance. Merck explains its cloud-based solution to close these gaps and mitigate risks by leveraging entitlements management and fine-grained provisioning to automate partner onboarding, connect required applications and data, assign permissions and control access by authenticating identities.

2:55 Why Would You NOT Use Public Clouds for Your Big Compute Workloads?

Jason Stowe, CEO, Cycle Computing

Up to now there’s been resistance to leveraging the cloud for the compute and data intensive workloads that historically run on in-house HPC environments. But genomics, computational chemistry, and other data collection and analytics have outpaced internal capacity. The lure of zero queue times, unlimited amounts of processing, and the ability to directly fit jobs to budget/value instead to available capacity is proving impossible to resist. This talk will highlight the risks and rewards of doing science in the cloud.

3:25 Refreshment Break in the Exhibit Hall with Poster Viewing


4:00 Custom Applications of Cloud-Based Analytics with Processed NGS Data (or, “My Pipelines Are Finished, Now What?”)

Jacob Feala, Ph.D., Founder, Outlier Bio

Cloud-based platforms allow us to scale out next-generation sequencing analysis pipelines. The explosion of NGS data, however, will require scalable storage and computing even for the reduced, preprocessed outputs downstream of these pipelines. I demonstrate oncology-focused applications of big data technology on downstream NGS outputs, such as alignments, variant calls and expression, using Amazon Redshift, Spark/ADAM and Amazon S3.

4:30 The ISB Cancer Genomics Cloud

Sheila Reynolds, Ph.D., Senior Research Scientist, Ilya Shmulevich Laboratory, Institute for Systems Biology

The ISB-CGC is a cloud-based platform that will serve as a large-scale data repository for TCGA data, while also providing the computational infrastructure and interactive exploratory tools necessary to carry out cancer genomics research at unprecedented scales. The ISB-CGC will provide both interactive and programmatic access to the TCGA data, leveraging many aspects of Google Cloud Platform including BigQuery and Compute Engine.

5:00 Sponsored Presentation (Opportunity Available)

5:30 – 6:30 Best of Show Awards Reception in the Exhibit Hall with Poster Viewing

Thursday, April 7

7:00 am Registration and Morning Coffee


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10:00 Coffee Break in the Exhibit Hall and Poster Competition Winners Announced


10:30 Chairperson’s Opening Remarks

10:40 Splicing-Centric Analysis of RNA-Seq Data Using the SpliceCore Platform

Martin Akerman, Ph.D., CTO & Co-Founder, Envisagenics, Inc.; Cold Spring Harbor Laboratory

Over 15% of disease mutations can cause structural errors in mRNA through Alternative Splicing (AS). SpliceCore is a cloud-based platform for AS discovery, analysis and interpretation using RNA-seq data. SpliceCore assists the increasing demand of data analysis and innovation for RNA therapeutics. I demonstrate SpliceCore in a breast cancer study case, including implementation and experimental validation in collaboration with Cold Spring Harbor Laboratory.

11:10 A Cloud Computing Infrastructure for BLAST

Thomas L. Madden, Ph.D., Staff Scientist, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health

The BLAST Cloud platform allows a user to perform a large number of sequence similarity searches. The platform supports queries through a REST style API, a webpage and command-line searches. There is minimal setup as a FUSE client downloads the latest database. We discuss the project design and performance as well as the use of this project in an existing workflow.

11:40 Sponsored Presentation (Opportunity Available)

12:10 pm Session Break

12:20 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own

1:20 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing


1:55 Chairperson’s Remarks

John M. Conley, J.D., Ph.D., William Rand Kenan, Jr. Professor of Law, University of North Carolina, Chapel Hill; Counsel, Robinson Bradshaw & Hinson


Taha A. Kass-Hout, M.D., MS, Chief Health Informatics Officer & Director, Office of Health Informatics, FDA

precisionFDA is an informatics cloud-based platform for ensuring the accuracy of Next-Generation Sequencing (NGS) tests by crowdsourcing reference material and data. A key part of President Obama’s Precision Medicine Initiative, it serves as a collaborative research effort that will inform later regulatory pathways and decision making. During this talk, Dr. Taha Kass-Hout, FDA’s Chief Health Informatics Officer, describes the platform and its successes since the December 2015 beta release. 

2:30 FEATURED PRESENTATION: How the Plecosystem, Blockchain, and Federated Data Enclaves will Shape Genomics Innovation and Application: Emerging Initiatives from the Global Alliance for Genomics and Health

John E. Mattison, M.D., Chief Medical Information Officer, Assistant Medical Director, Southern California Medical Group, Kaiser Permanente; Co-Chair, eHealth Workgroup, Global Alliance for Genomics and Health GA4GH

How can we maximize genomic research for the good of all citizens without violating their privacy? We need powerful new approaches to ensure ethical research without unwarranted risk to citizens who consent to use of personal data. The Global Alliance for Genomics and Health includes worldwide institutions seeking consensus on policy frameworks supported by creative technical solutions to achieve these paired goals of higher value and lower risk. I discuss progress to date.

3:00 FEATURED PRESENTATION: Large-Scale Data Commons for Genomic and Clinical Data and the Changing Landscape for Sharing Research Data

Robert Grossman, Ph.D., Director, Center for Data Intensive Science (CDIS); Core Faculty, Institute for Genomics & Systems Biology and Computation Institute, Professor of Medicine, Section of Genetic Medicine, University of Chicago

Open commons containing large amounts of public biomedical data from the research community can potentially dramatically speed up medical research. We describe our experiences developing large-scale open source data commons for genomic and associated clinical data. We also discuss options for integrating and interoperating in-house genomic and clinical data with public data commons and private data partnerships.

3:30 PANEL DISCUSSION: How Will Data Sharing Innovations Fare in the Regulatory Environment?

Moderator: John M. Conley, J.D., Ph.D., William Rand Kenan, Jr. Professor of Law, University of North Carolina, Chapel Hill; Counsel, Robinson Bradshaw & Hinson


Robert Grossman, Ph.D., University of Chicago

Taha A. Kass-Hout, M.D., MS, FDA

John E. Mattison, M.D., Kaiser Permanente

Additional Panelists to be Announced

4:00 Conference Adjourns

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  • Making the World's Knowledge Computable
  • Bioinformatics in the Cloud
  • The Application of Text Analytics to Drug Safety Surveillance

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