BIT Header Desktop  
BIT Header Mobile 
2014 Archived Content

Collaborations and Open Access Innovations 

Track 11 explores best practices in collaboration and information sharing that helps to drive progress in translational research. Case studies will be presented to show new insights on key drivers, technology innovations, collaboration platforms, open-source frameworks, and other factors that are managing analytical data and empowering transformative changes through translation. Additional topics to be covered include portals (website, research, collaboration) and their applications, data liquidity, and technical and cultural obstacles.

Final Agenda


Download Brochure | Pre-Conference Workshops 


TUESDAY, APRIL 29


7:00 am Workshop Registration and Morning Coffee

8:00 - 11:30 Recommended Morning Pre-Conference Workshops*

Analyzing NGS Data in Galaxy

12:30 - 4:00 pm Recommended Afternoon Pre-Conference Workshops*

Running a Local Galaxy Instance
The tranSMART Platform Today and Tomorrow
IT & Informatics in Support of Collaboration and Externalization

*Separate Registration Required. Click here for detailed information.


2:00 - 7:00 pm Main Conference Registration

4:00 Event Chairperson's Opening Remarks

Cindy Crowninshield, RD, LDN, Conference Director, Cambridge Healthtech Institute


4:05 PLENARY KEYNOTE SESSION 

Click here for detailed information. 


5:00 – 7:00 Welcome Reception in the Exhibit Hall with Poster Viewing

 

 


WEDNESDAY, APRIL 30

7:00 am Registration Open and Morning Coffee

8:00 Chairperson's Opening Remarks

Phillips Kuhl, Co-Founder and President, Cambridge Healthtech Institute


8:05 PLENARY KEYNOTE SESSION 

Click here for detailed information. 


9:00 Benjamin Franklin Award & Laureate Presentation

9:30 Best Practices Awards Program

9:45 Coffee Break in the Exhibit Hall with Poster Viewing


Collaborating in Chronic and Rare Diseases 

10:50 Chairperson's Remarks

Marcia Kean, Chairman, Strategic Initiatives, Feinstein Kean Healthcare

11:00 PANEL DISCUSSION: Patient-Powered Research Networks: Surge in the War against MS and other Diseases

Marcia Kean, Chairman, Strategic Initiatives, Feinstein Kean Healthcare

Kenneth Buetow, Ph.D., Director of Computational Sciences and Informatics, Complex Adaptive Systems Initiative (CASI), Arizona State University

Dave King, Founder and CEO, Exaptive, Inc.

Joe Laferrera, Partner, J.D., Gesmer Updegrove LLP

Sara Loud, MSEE, MBA, Repository and Operations Director, Accelerated Cure Project for Multiple Sclerosis

Driven by increasing consumer demand for knowledge, as well as the mandate of the Patient-Centered Outcomes Research Institute (PCORI), a new model for collection, integration, aggregation and analysis of data is emerging in which the patient is central. With an award from PCORI, the Accelerated Cure Project for MS, with its members and partners, are launching the iConquerMS portal for such patient empowerment, to speed and enhance research into MS and then to apply the model to other neurological diseases.

12:00 pm Co-Presentation: Collaboration to Support Translational Research to Transform R&D

Hongyue Dai, Ph.D., Chief Bioinformatics Officer, M2Gen

Asif Dhar, Ph.D., M.D., Executive Vice President Solutions, ConvergeHEALTH by Deloitte

Join M2Gen and Deloitte as they discuss their collaboration to support personalized medicine and review case studies leveraging informatics to transform the industry.

12:15 Analysis of TCGA Data with User-Friendly Tools for Cancer Genomics
M. Michael Barmada, Ph.D., Associate Professor, Human Genetics and Biomedical Informatics, University of Pittsburgh 
Next-generation sequencing enables cancer researchers to identify biomarker, which can be used as new drug targets, prognosis, and diagnosis. However, facilitating the data analysis in a user-friendly way is still a bottleneck. Here we present the analysis of TCGA data using an intuitive and customizable software solution as an example for rapid and accurate interpretation of advanced NGS sequencing data. 

12:40 Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own

1:50 Chairperson's Remarks
Alexander Wait Zaranek, Ph.D., Director Informatics, Personal Genome Project, Harvard Medical School 

1:55 Collaborating in Rare Diseases through Technology

Alex Sherman, Director, Strategic Development and Systems, Neurological Clinical Research Institute, Massachusetts General Hospital

Rare diseases have to self-organize to become attractive to pharma/biotech industry. Collaborative technology and methodology allow information to be aggregated and harmonized from heterogeneous sources, including patient registries, Electronic Health Records, biorepositories, and clinical and research databases. Global Patient Identifier helps to link it all together. Evolving crowd-sourcing and crowd-funding initiatives allow multiply number of people participating in medical research and data analyses.

2:25 Accelerating Rare and Chronic Disease Research with Transparent Informatics

Alexander Wait Zaranek, Ph.D., Director Informatics, Personal Genome Project, Harvard Medical School

Rapid improvements in DNA sequencing and synthesis could usher in a new era of precision medicine. The Personal Genome Project is building a transparent and public resource consisting of genomes, detailed phenotypes, software, as well as cell-lines and other tissue samples for more than 100,000 individuals. However, the effort to address computational and storage needs created by genomic and other types of molecular data are not well served by a fragmented landscape of homegrown solutions and proprietary technologies. An open-source foundation can help coordinate the efforts of stakeholders around open biomedical infrastructure. The open data, interactive applications and cloud infrastructure developed at the PGP can provide the initial seed for the initiative. 

 

2:55 Accelrys ScienceCloud: A Hosted Strategies for Collaborative R&D

Matt Hahn, Ph.D., CTO, Accelrys

The life sciences industry has been undergoing dramatic changes and effective global collaboration has become a key success factor in this new age. Accelrys is providing a hosted and comprehensive solution stack for externalized, collaborative research for pharma/biotech and CROs to address these new challenges.

3:25 Refreshment Break in the Exhibit Hall with Poster Viewing


Collaboration and Externalization in R&D 

4:00 Co-Presentation: Informatics Paradox: Separating and Collaborating in Life Science

Sarah Blendermann, Senior Director, Chemistry & Pharmacology, Business Technology, Pfizer

Rick Somes, Senior Director, Acquisitions, Divestitures and Restructuring R&D Business Technology, Pfizer

The organization was running operations and discovery while separating data and systems. Collaboration and segregation were key components of the informatics required to successfully meet an IPO timeline. A long-term collaboration agreement means ties between the organizations will remain, requiring longer-term technical solutions for granular security, collaboration, and data sharing.

4:30 Towards the Intelligent and Automated Analytical Laboratory

Dave Hartsough, Ph.D., Executive Director, Sites, Benchtop, & Validation R&D Informatics, Amgen

This presentation will provide an update on the progress of the Allotrope Foundation towards delivering an open Framework solution for managing analytical data throughout its lifecycle and will include details on the deliverables, timelines, and results from completed proof-of-concept applications based upon the initial proposal and analysis presented in 2013.

5:00 Growing our Innovation Capability from the Inside-Out: AstraZeneca’s Journey to a New Way of Working
Scott Wilkins, Ph.D., Enterprise Innovation Director, AstraZeneca 

5:30 - 6:30 Best of Show Awards Reception in the Exhibit Hall


THURSDAY, MAY 1

7:00 am Registration Open

7:00 Breakfast Presentation (Sponsorship Opportunity Available) or Morning Coffee

8:00 Chairperson’s Opening Remarks

Kevin Davies, Ph.D., Vice President Business Development & Publisher C&EN, American Chemical Society; Founding Editor, Bio-IT World


8:05 PLENARY KEYNOTE SESSION 

Click here for detailed information. 


10:00 Coffee Break in the Exhibit Hall and Poster Competition Winners Announced


Collaborative Approaches to Clinical Data 

10:30 Chairperson's Opening Remarks

Thomas Verish, Group Director, Data Operations Services, Bristol-Myers Squibb

10:35 PANEL DISCUSSION: Forming a Collaborative Approach to Develop a Data and Technology Blueprint

Muzafar Mirza, Director, Information Strategy and Analytics, Clinical Informatics and Innovation, Pfizer, Inc.

Georgina Wood, Global Head, Technology Innovations, Novartis

Francis Kendall, Global Head, Statistical Programming and Analysis, Roche

Thomas Verish, Group Director, Data Operations Services, Bristol-Myers Squibb

Brooke Hinkson, Global Head, Clinical Information Governance, Clinical Sciences & Operations, Sanofi

This panel is a read-out of a collaboration between several pharma companies with the prime objective of devising solutions to the challenges that we face as an industry. This cross-pharma consortium focused discussions on technology, standards and data with a view to creating a common framework for how we process data especially in the changing data landscape. Key focus areas included: Transition to CDSIC, Data Aggregation (including broad categories of data - Clinical Trial data, Payer databases, Registry data, Electronic Medical Records Genome data, Biomarker data and Legacy data), key technologies related to data warehousing/data reporting, validation of data analysis tools and open source approaches.

12:15 pm Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own

1:15 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing

1:55 Chairperson's Remarks
Scott Wilkins, Ph.D., Enterprise Innovation Director, AstraZeneca 

2:00 Interactive Medical Literature: ITN TrialShare for Open Access in Clinical Trials

Adam Asare, Ph.D., Senior Director, Bioinformatics, Immune Tolerance Network

The Immune Tolerance Network (ITN) recently achieved an unprecedented milestone in clinical trial transparency through a high profile publication in the New England Journal of Medicine that included links to the underlying clinical data and analysis code in the ITN TrialShare web portal (www.itntrialshare.org). This marks a significant advance in data sharing and transparency, allowing researchers the ability to access study data, confirm published conclusions and interactively perform their own exploratory analyses. The presentation includes lessons learned in creating interactive publications with embedded URL links and its impact on the manuscript development and review process. Metrics on system usage will also be highlighted along with scientific collaborations developed.


Consortia Efforts: Updates, Opportunities, Discussion 

Speakers will give a 15-20 minute presentation about their consortia efforts and then convene for a panel discussion.

2:30 Open PHACTS: Practical Semantics for Drug Discovery

Lee Harland, Ph.D., CTO, Open PHACTS, Connected Discovery

The Open PHACTS project is a €20 Million collaboration between major pharma and a range of top academic institutes. Its mission it to create an open, pre-competitive, cloud-based data integration and analysis platform. This talk will describe the journey and the outcome of a major effort in applying semantic technologies to drug discovery and provide a vision for future collaboration across pharma and biotech in this area.

2:50 Enable Unified Analysis and Mining of Biological and Chemical Data from Various Sources

Daniel Stoffler, Ph.D., Senior Principal Scientist, Group Leader Cheminformatics & Statistics, F. Hoffmann-La Roche Ltd, Basel

Computational methods that rely on historical activity data such as target identification in phenotypic screens or virtual screenings based on biological profiles, compound repurposing or pathway identification have been limited due to the inaccessibility or fragmentation of the various data sources. This undertaking will capitalize on the IMI ‘OpenPHACTS’ initiative and will use novel approaches to allow scientist accessing internal and external Chemical and Biological data sources through one interface.

3:10 The European Translational Research Information and Knowledge Management Services (eTRIKS): 18 Months into a Novel IMI Project to Support Translational Research Data Management

Jay Bergeron, Director, Translational and Bioinformatics, Pfizer

eTRIKS has delivered substantial value to the translational data management community including acting as the key development partner for creating a fully open source version of the tranSMART platform (using PostgreSQL). eTRIKS has released (Nov 2013) a public server including clinical and molecular studies and is continuing to implement a tranSMART-based roadmap that includes emerging security, analytic and semantic capabilities.

3:30 tranSMART: Enabling Rapid Exploratory Analyses and Hypothesis Generation at Pfizer

Angela Gaudette, Business Analyst, Research Business Technology, Pfizer

Many organizations are seeking ways of supporting clinical endpoint and biomarker information generated by human studies and would benefit from a platform that consistently manages these data while allowing for collaborative information sharing and transfer both internally and externally. We will share our experience at Pfizer with our adoption of tranSMART, an open source platform. Learn how Pfizer has contributed to this open source initiative by enabling the search and visualization of Genome Wide Association Studies within the tranSMART platform and discover the potential of such a platform through a neuroscience case study.

3:50 PANEL DISCUSSION with Speakers

4:00 Conference Adjourns

*IBM and the IBM logo are trademarks of International Business Machines Corp., registered in many jurisdictions worldwide. 



Download Brochure | Pre-Conference Workshops 



View 2015 Brochure
 BIT-Agenda-icon 

Platinum Sponsors
 
Aspera 

 Cycle Computing logo 

 Data Direct Networks 

Elsevier 

 

IBM 

Illumnia logo 

Intel Logo 

OKTA 

Oracle Health Sciences 

Seagate  

 SGI small logo 

Thinkmate 

Thomson Reuters 


View All Sponsors 

 


Official Media Partner
  


View Media Partners 


Conference CD

CD iconOrder the 2014 event proceedings - now available on CD 


Complimentary Downloads

View white papers, listen to podcasts, and more! 

  • Making the World's Knowledge Computable
  • Bioinformatics in the Cloud
  • The Application of Text Analytics to Drug Safety Surveillance
 

Related Events

 HIT Logo for BIT 2015
CLN Co-located Event