BIT Header Desktop  
BIT Header Mobile 
 

Track 10 - April 21 – 23, 2015

Collaborations and Open Access Innovations 

Using Collaborative Technologies and Methodologies to Accelerate Basic, Translational and Clinical Research

Track 10 presents case studies on collaborative technologies and methodologies used to aggregate and harmonize data from heterogeneous sources to accelerate basic, translational and clinical research. Speakers will show novel approaches of key drivers, technology innovations, collaboration platforms, open-source frameworks, and other factors that are managing data and empowering transformative changes through translation. Additional themes that will be covered include emerging security, analytic and semantic capabilities.

Final Agenda


Tuesday, April 21


Download Brochure | Workshops 

7:00 am Workshop Registration and Morning Coffee

 

8:00 – 11:30 Recommended Morning Pre-Conference Workshops*

Gamification of Science

12:30 – 4:00 pm Recommended Afternoon Pre-Conference Workshops*

How Data-Driven Patient Networks are Transforming Biomedical Research

IT & Informatics in Support of Collaboration and Externalization

* Separate registration required

2:00 – 6:30 Main Conference Registration

 

4:00 PLENARY SESSION  

Click here for detailed information.  

5:00 – 7:00 Welcome Reception in the Exhibit Hall with Poster Viewing


Wednesday, April 22

 

7:00 am Registration Open and Morning Coffee

 

8:00 PLENARY SESSION  

Click here for detailed information.  

9:00 Benjamin Franklin Awards and Laureate Presentation

9:30 Best Practices Awards Program

9:45 Coffee Break in the Exhibit Hall with Poster Viewing


OPEN SOURCE SOFTWARE & STANDARDS 

10:50 Chairperson’s Opening Remarks

11:00 Imitation and Disruption: Impact on Open Source Software Success in the Life Sciences

Jay Bergeron, Director, Translational and Bioinformatics, Pfizer, Inc.

There are many successful examples of open source software (OSS) both within and outside of the life sciences community. However, investigators sponsoring software-based efforts need to consider many factors, including resourcing, architecture fragmentation, maintenance and their customer community when selecting between commercial and open license alternatives. This presentation will review such factors. Motivations that give rise to voluntary participation, by software developers, in OSS projects have been well analyzed. Socio-Psychological factors that include the potential for individual development and personal recognition, as well as the opportunity to contribute to self-selected high value efforts, have been promoted as drivers of OSS contribution. Substantial work has been conducted to relate architectural elements with the free-rider tolerance that is associated with successful OSS initiatives. However, empirical evidence to support the hypothesized relationship between architecture and OSS participation is limited. Moreover, the extent to which Socio-Psychological factors promote OSS participation is difficult to quantify given substantial OSS investments that are provided by government and commercial enterprises. Additionally, open source licensing models may not preclude commercial extension, packaging and consultancies. To extend the traditional dialog regarding OSS implementation, imitation of existing business patterns and discretionary pricing models that enable under-served customers, leading to market disruption, are considered as key drivers of OSS success.
Jay Bergeron is the Director, Translational and Bioinformatics at Pfizer with my team being responsible for informatics support for Clinical Research and Precision Medicine. I am also the Scientific Coordinator of eTRIKS (European Translational Research and Information Knowledge Management Services), a 23M Eu program to support translational data management for the IMI that uses Open Source Software (tranSMART) as the core system. I am also co-lead of the code committee of the tranSMART Foundation, a non profit community organizer for the Open Source tranSMART application. The work to be presented was conducted as part of a MBA thesis associated with faculty at the Rensselaer Polytechnic Institute.
 

11:30 OpenBEL: Collaborative Knowledge Base and Tools for Biomedical Research

Natalie Catlett, Ph.D., Senior Computational Scientist, Engineering, Selventa

Anthony Bargnesi, Application Architect, Engineering, Selventa

OpenBEL is an open source platform for managing biological knowledge, comprised of the Biological Expression Language (BEL) and a knowledgebase platform. BEL is a standard for qualitative representation of cause and effect relationships in molecular biology in a format that is both computable and human readable. The BEL knowledgebase platform compiles BEL knowledge from heterogeneous sources into cohesive networks that can be used for a broad range of biopharma, academic, or goverment research applications including the interpretation of large-scale 'omic data sets and modeling cellular responses. We will describe a next-generation Semantic Web RDF platform for harmonization, storage, and access of BEL knowledge; language expansion; and development of an exchange format for biological models derived from BEL knowledge networks.

12:00 pm Sponsored Presentation (Opportunity Available) 

12:30 Session Break

12:40 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own

1:40 Session Break


COLLABORATIVE APPROACHES IN CLINICAL RESEARCH, BIOMEDICAL RESEARCH AND THE PHARMACEUTICAL SPACE 

1:50 Chairperson’s Remarks

1:55 One Pharmaceutical’s Journey to a Beacon

Karen King, Head, Genetic Data Sciences, Genetics, GlaxoSmithKline

The Global Alliance for Genomics and Health issued a challenge to demonstrate willingness to share data by creating a public web-based “beacon” that responds to a simple query. This “beacon” is technically simple and the data non-identifiable. We present one pharmaceutical’s journey to creating a beacon, and bring to the table for discussion some of the challenges encountered along the way.

2:25 NeuroBANK™, Accelerated Research Environment as a Model for Collaboration and Cooperation in Clinical Research

Alex Sherman, Director, Strategic Development and Systems, Neurological Clinical Research Institute, Massachusetts General Hospital

NeuroBANK™, a patient-centric platform that allows clinicians and investigators to aggregate and cross-link clinical and research information from clinical visits, clinical studies, health records, and self-reported patient outcomes, and to connect it to biospecimen, images and genetic files. Will discuss how to find or create incentives for collaborations. The system is also utilized in two patient-centered research networks (PPRNs) of PCORnet. Utilization of the Global Unique Patient Identifier (GUID), first ever in ALS research, allows to link information in NeuroBANK™ to biospecimen, image banks and genetic material collections. Comparative effectiveness research and practice quality improvement become a standard and achievable objective.

2:55 Sponsored Presentation (Opportunity Available)

3:25 Refreshment Break in the Exhibit Hall with Poster Viewing


COLLABORATING IN CHRONIC AND RARE DISEASES 

4:00 CureAccelerator™: How a New Global Platform Will Help Propel Cures for the World’s Unsolved Diseases

Bruce Bloom, D.D.S., J.D., President and Chief Science Officer, Cures Within Reach

More than 7,000 diseases have no fully effective treatment, affecting more than 500 million people worldwide. Conceived by Cures Within Reach, CureAccelerator™ is the world’s first open-access, online platform dedicated to repurposing research – the quest to create new medical treatments from existing therapies, to drive more cures more quickly to more patients. Learn how this innovative IT tool will enable researchers, funders, the biomedical industry and patient groups to collaborate far more efficiently, to propel the pace of repurposing research. Platform features include: Global access. Various levels of transparency, from fully open forums to invitation-only, to facilitate the free flow of ideas while protecting privacy and intellectual property. Highly customizable dashboard, filters, searches and other features to prevent information overload and speed “matchmaking” among researchers, funders and others who are focused on the same disease state or target treatment. 

4:30 Delivering on a Promise: Achieving a Patient-Centric Open Information Ecosystem

Walter Capone, President and CEO, The Multiple Myeloma Research Foundation

Patient-centric, open access research models are widely acknowledged catalysts of scientific and medical progress. Yet despite the benefits, in practice these models are rarely achieved. From misaligned incentives among stakeholders to inadequate technologies, there are a myriad of challenges that must be overcome to turn these noble ambitions into reality. Here we present a first-in-kind model for combining an observational clinical study with a participatory, community driven research program for Multiple Myeloma, and in doing so, providing a powerful example that can lead the way forward in other disease areas.

5:00 Sponsored Presentation (Opportunity Available)

5:30 Best of Show Awards Reception in the Exhibit Hall with Poster Viewing

6:30 Close of Day


Thursday, April 23

 

7:00 am Registration and Morning Coffee

 

8:00 PLENARY SESSION PANEL 

Click here for detailed information.  

 

10:00 Coffee Break in the Exhibit Hall and Poster Competition Winners Announced


COLLABORATING IN CHRONIC AND RARE DISEASES 

10:30 Chairperson’s Remarks

10:40 PANEL DISCUSSION: Multiple Sclerosis Conquered by the Data Science Revolution: Patients Win

Ken Buetow, Ph.D., Director, Computational Sciences and Informatics, Arizona State University

Robert McBurney, CEO, Office of the Chief Executive, Accelerated Cure Project

Marcia Kean, Chairman, Strategic Initiatives, Feinstein Kean Healthcare

Joseph LaFerrera, J.D., Partner, Gesmer Updegrove LLP

Funded by a grant from PCORI (Patient-Centered Outcomes Research Institute), the Accelerated Cure Project for MS is collaborating with all the key organizations in the MS community, gathering patient-reported and EHRs from 20,000 patients. It’s a best-practice model for data-enabled research; patient-centricity; and public-private partnerships. The key players from life sciences, data sciences, medicine patient advocacy and communications will describe the winning formulas that are making it successful. Attendees will learn how to design and fund such an initiative; how to collect standards-based data including the horrendous challenges around EHRs; best tools for analytics and data visualization; handling research queries; and overcoming the traditional silos that prevent seamless data exchange and global big data-enable basic, clinical and comparative effectiveness research.

CONSORTIA EFFORTS: UPDATES, OPPORTUNITIES AND DISCUSSION  

11:40 The Open PHACTS Foundation - Semantic Data Integration for Life Sciences

Bryn Williams-Jones, Founder & Chief Operating Officer, Open PHACTS, Connected Discovery

Building on the success of the Open PHACTS IMI project, the Open PHACTS Foundation is a not-for-profit membership organisation, supporting the Open PHACTS Discovery Platform: A sustainable, open, vibrant and interoperable information infrastructure for applied life science research and development. To reduce the barriers to drug discovery in industry, academia and for SMEs, the Open PHACTS Discovery Platform provides tools and services to interact with multiple integrated and publicly available data sources. To integrate this data, extensive cross-referencing of scientific concepts is needed across all databases – a task currently involving 18 million links. Building on the success of the IMI public private partnership model, The Open PHACTS Foundation is leveraging the community of users to bring new data sources, tools and analysis to key drug discovery and development business questions. We will describe some of the capabilities of The Open PHACTS Discovery Platform, as well as show how commitment to pre-competitive and open innovation remains at the heart of The Open PHACTS Foundation with opportunities for all to get involved.

12:10 pm Session Break
 

12:20 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own

1:20 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing

1:55 Chairperson’s Remarks

2:00 Incubating Open Innovation - the IMI2 Case Study

Anthony Rowe, Ph.D., Principal Research Scientist, External Innovation R&D IT, Janssen R&D, LLC

After a set of successful Innovative Medicine Initiative (IMI) public-private consortia has been launched the learnings from the first 6 years now informing how the processes in the follow on IMI2 could be refined. One particular area of interest is how to improve the incubation of new project ideas which eventually lead to pre-competitive open innovation projects. In this presentation we will describe the mechanism how the European Federation of Pharmaceutical Industry and Associations is handling this opportunity as well as the initial experiences of a particular group.

2:30 Allotrope Foundation: A Collaboration Making Real Progress Addressing the Data Management Problems Facing the Analytical Laboratory

Dana Vanderwall, Ph.D., Associate Director, Cheminformatics, Research Information Technology and Automation, Bristol-Myers Squibb

Allotrope Foundation is building a framework (a software toolkit) to embed a set of public, non-proprietary standards for analytical data in software utilized throughout the entire analytical chemistry data lifecycle. We will discuss why embedding standards addresses the fundamental, root causes of our data challenges, rather than merely treating symptoms of the problem. This standards-based, community-driven approach, where people who make devices (laboratory instruments) are collaborating with those who create and depend on analytical data (the industry) to transform how we create, use, disseminate and manage scientific data through the creation of innovative products. We will provide an update on the rapid progress in the first year of development, which has demonstrated that the core concepts of the Allotrope Framework are technically feasible through the creation and delivery of proof of concept framework components and applications. The project has moved from concepts to reality, with tangible capabilities and software that have begun delivering the vision of Allotrope Foundation. The next phase of work will be discussed including finalization the Allotrope data and metadata format, the first release of APIs (application programming interface) and collaborations with the vendor community as well as the long term plans for deployment. The audience will learn about Allotrope Foundation and the substantive progress in the development of the Framework including:
• The completed architecture and implementation of a basic framework that handles the standard data format, contextual metadata and workflow concepts
• The metadata repository, related services and APIs
• The completed proof-of-concept applications (PoCs) the use using the initial Framework and enabled the evaluation and testing of standards for document format, metadata and implementation. This enabled the demonstration of capabilities that use a standard document format and metadata.
• The standard interfaces (APIs) created using established software development standards for all Framework capabilities built and which were used in PoCs and between Framework components
• The novel data archiving concept demonstrated with enriched with standard metadata definitions acquired in workflow or added post-hoc in the archiving step and using a vendor-independent data format.
• The design and implementation of the Allotrope standard file format for data and metadata, which leverages many existing standards in analytical, as well as general scientific, and big data domains.
• The roadmap to build out that Framework to the level of functionality and robustness required for use in production by pharma/biopharma companies and vendors. This will enable solutions for managing analytical data that are fundamentally different than what is available today, and for Allotrope Foundation members to realize the far reaching benefits and return on investment that define our vision.
• Finally, we will explain how stakeholders in the analytical community can work with us through collaboration, expert advice, and active membership.

3:00 Creating an Open Innovation Platform for the Promotion of Precompetitive Collaboration – The Pistoia Alliance’s Interactive Project Portfolio Platform (IP3)

Carmen Nitsche, Executive Director Business Development North America, Pistoia Alliance

In order to promote the free exchange of ideas and increase the transparency of the portfolio development process, the Pistoia Alliance recently launched its Interactive Project Portfolio Platform (IP3). Members and non-members alike can review and contribute to the pool of ideas and assist in their evaluation. The membership then prioritizes and funds the top projects that address immediate and universal pain points within the precompetitive arena of Life Sciences R&D. In this talk we will review the development and application of the platform as a key tool to advance the Pistoia Alliance’s mission.

3:30 The New tranSMART Platform v1.2 Provides Unparalleled Functionality for Translational Medicine

Rudy Potenzone, Ph.D., Vice President, Marketing, tranSMART Foundation

The tranSMART Platform is in active use by over 50 organizations worldwide and the basis for a growing number of large data integration and analysis projects. It is becoming the premier platform for translational studies as the Community continues to expand this Open Source platform by their contributions. Learn about the Platform, see a large number of user examples and see the breadth of the user community contributing to the Platform.

4:00 Conference Adjourns


Download Brochure | Workshops 



View 2015 Brochure
 BIT-Agenda-icon 

Platinum Sponsors
 
Aspera 

 Cycle Computing logo 

 Data Direct Networks 

Elsevier 

 

IBM 

Illumnia logo 

Intel Logo 

OKTA 

Oracle Health Sciences 

Seagate  

 SGI small logo 

Thinkmate 

Thomson Reuters 


View All Sponsors 

 


Official Media Partner
  


View Media Partners 


Conference CD

CD iconOrder the 2014 event proceedings - now available on CD 


Complimentary Downloads

View white papers, listen to podcasts, and more! 

  • Making the World's Knowledge Computable
  • Bioinformatics in the Cloud
  • The Application of Text Analytics to Drug Safety Surveillance
 

Related Events

 HIT Logo for BIT 2015
CLN Co-located Event