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Bio-IT World Weekly Update 
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A Bio-IT World publication 
  Tuesday, February 02, 2010    |  Bio-ITWorld.com  |  Archives  |  Advertising  |  Your Account  |  CHI Conferences  |    Subscribe  | 
 
 
 
 

Industry Trends 

The "Net Innovation Trend" and What it Means for Big Pharmas, Biotechs, and Generics 

By Mark P. Mathieu 

Innovation is the key value driver in healthcare. Over the past 8 years, the pharmaceuticals sector has lost a stunning $593 billion (-65%) in market cap while the two sectors with innovation - biotech and med tech - have each added $71 billion (+46%) and $19 billion (+6%) in market cap, respectively.
Read more 

 

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IN THIS ISSUE 
  Oxford Nanopore Raises $28 Million in New Funds 
  Running tranSMART for the Drug Development Marathon 
  Life Technologies SOLiD 4 System Sights $6000 Genome 
  Avila Therapeutics Targets the Covalent Proteome 
  Drug Discovery, Open-Source Style 
 
 
 

Counting Down to Bio-IT World Expo 2010 

We are less than three months away from the kick off to the 2010 Bio-IT World Expo in Boston, being held from April 20-22). All signs point to a brilliant event, with registrations pouring in and exhibitors scrambling for the final few booths. We hope you'll consider joining us.

Our confirmed keynotes include Christoph Westphal, co-founder and CEO of Sirtris Pharmaceuticals and senior VP for external drug discovery at GlaxoSmithKline, which snapped up Sirtris for a cool $700 million last year. Sirtris attracted a wealth of media attention for its successful work in developing drugs called sirtuins, which act along the lines of resveratrol, the active ingredient in red wine. Westphal has an unparalleled view of the challenges and opportunities facing the pharma industry, and it will be great to hear how the former venture capitalist and entrepreneur is now trying to innovate pharma from within.

We'll also welcome John Halamka, CIO of Harvard Medical School, and an authority of electronic medical records, health informatics, and one of the first ten intrepid volunteers for George Church's Personal Genome Project. Halamka is one of the country's key figures in the ongoing healthcare debate, advising the government on technology solutions for modernizing health care records, not to mention the challenge of running the IT and data management tools for one of the country's largest and most prestigious medical schools.

We'll be announcing our third keynote very shortly, and think it will fit in superbly with the direction of the bio-IT field. Stay tuned!
The opening day, April 20, features a series of pre-conference workshops on topics including cloud computing, imaging informatics, text mining and next-generation sequencing. These are dynamic, information-rich sessions, not to mention fabulous networking opportunities.

Our main conference features seven tracks, from IT infrastructure to bioinformaitcs and next-gen data analysis, cheminformatics and molecular modeling to e-clinical research and e-health. Just a few of our confirmed speakers include Sandy Aronson (Partners Healthcare), Toby Bloom (Broad Institute), Phil Bourne (UCSD/PLoS Computational Biology), Ken Buetow (caBIG), Phil Butcher (Sanger Institute), Stephen Friend (Sage Bionetworks), William Hayes (Biogen-Idec), James Heywood (PatientsLikeMe), Craig Lipset (Pfizer), Pardis Sabeti (Harvard), John Oberington (EMBL-EBI), Eric Perakslis (J&J), and Mollie Shields-Uehling (SAFE-Biopharma).
There are plenty of other highlights as well, including the Benjamin Franklin Award for bioinformatics and the 2010 Best Practices Awards dinner on April 21, where some 200 guests will be the first to learn and hear from the winners of this year's competition. (There is still time to enter the competition!) And we're looking forward to the Best Of Show competition, always a competitive event to recognize the most outstanding new products on the exhibit hall floor.

Bio-IT World Expo debuted in 2002, and for those of us associated with the event in all that time, it is incredibly gratifying to see the event truly gaining momentum. Please join us for the show, or if you just want to pop in and hear 1-2 keynotes, apply for a complimentary exhibit hall/keynote pass. See you in April!

Kevin Davies
Editor, Bio-IT World
 

 
THIS WEEK IN BIO-IT 
 

Oxford Nanopore Raises $28 Million in New Funds
By Kevin Davies 

One of the most exciting companies developing third-generation DNA sequencing platforms, the UK's Oxford Nanopore Technologies, has raised a further $28 million in new funding. Read more. 

 

Running tranSMART for the Drug Development Marathon
By Kevin Davies 

If you sense a certain irresistible Lance Armstrong-like determination when meeting Centocor's Eric Perakslis, it is not a coincidence. Perakslis, the VP of R&D Informatics at Centocor R&D (and newly appointed member of the Corporate Office of Science and Technology at J&J) is a cancer survivor-he was diagnosed with stage III kidney cancer at 38-and has run marathons in support of Armstrong's LiveStrong Foundation. Read more. 

 

Life Technologies SOLiD 4 System Sights $6000 Genome
By Kevin Davies 

Life Technologies has introduced the latest version of its next-generation sequencing system, the Applied Biosystems SOLiD 4, with a throughput of 100 Gigabases and a reagent cost of $6,000 per human genome. Read more. 

 

Avila Therapeutics Targets the Covalent Proteome
By John Russell 

Imagine administering a small-molecule drug that could effectively, specifically, and permanently silence its protein target. That should be the ideal of any drug-discovery program, but most small-molecule drugs interact with their target in a reversible, transient and depressingly non-specific manner. One solution to the problem would be to focus on a different class of small molecules-compounds that form a strong, covalent bond with their desired target. Read more. 

 
 

Drug Discovery, Open-Source Style
By Allison Proffitt 

'We are putting into practice the philosophy of open-source software: that given enough eyeballs, all bugs are shallow." So says Zakir Thomas, project director of Open Source Drug Discovery, or OSDD. Established in India, OSDD has established a novel open-source platform for both computational and experimental technologies to make drug discovery for infectious and neglected diseases cost effective and affordable to the people of the developing world. Read more. 

 
 

Last Week's Most-Read Story
Illumina's HiSeq 2000: Secrets and Buys 

 

Bio-IT Briefs
January 26 | Full Stories 

  • Health Decisions president publishes agile trial book 
  • GATC Biotech purchases new Illumina platform 
  • Genedata and Bayer Schering Pharma AG announce multi-year collaboration 
 
 
 
 
ELSEWHERE IN THE PRESS 
 

Counsyl Brings Gene Tests to Masses
Counsyl, a Silicon Valley start-up, aims to help eradicate more than 100 genetic diseases by offering a $349-per-person test that can alert parents-to-be of their risks of having children with a range of inherited diseases, including cystic fibross, Tay-Sachs, and Pompe disease (featured in the new Harrison Ford movie Extraordinary Measures). New York Times

Bill Gates Pledges $10 Billion for 'Decade of Vaccine'
At the World Economic Forum in Davos, Switzerland, Bill Gates announced the largest ever single charitable donation -- $10 billion over ten years -- which he hoped would mark the "decade of the vaccine," saving 8 million lives. The Times 

Bristol-Myers Squibb Advances String of Pearls Strategy
In December Bristol-Myers Squibb traded away its last remaining shares in businesses that don't support the "String of Pearls" strategy the company announced in August 2008. ABC News 

Dan Vasella Steps Down as Novartis CEO
Daniel Vasella stunned investors on Tuesday by saying he was stepping down as Novartis CEO.  Forbes 

 

 

 

WEBINAR
Next-Generation Clinical Trial and Data Management Applications 
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  • Enterprise solutions based on Adobe LiveCycle® ES utilizing cross-platform clients of Reader, Flash and AIR 

Download now. 

To have your podcast featured here, contact Lynn Cloonan for more information. 

 

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To have your product or service featured here, contact Lynn Cloonan  for more information. 
 

Insight Pharma Reports

Multiplex Assays: Evolving Technologies, Applications, & Future Directions
 
Author: Ken Rubenstein, Ph.D. 

Multiplex Assays has generated a great deal of excitement in the past 15 years.  This report examines the role of multiplex and multi-analyte biomarker assays in translational medicine.  Read more . 

 

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BEST PRACTICES 2010
Deadline Extended 

The deadline for the 2010 Bio-IT World Best Practices Awards Program has been extended to  February 19, 2010. 

Share your organization's best practices with your peers. The Best Practices program recognizes individuals and teams for their novel and innovative uses of technology, business strategies, and solutions that improve some facet of the R&D / drug development / clinical trial process.  Direct entries are encouraged as well as nominations from users and vendors.

"We're excited about this award and very honored to be a recipient of Best Practices from Bio-IT World."  -Vanderbilt University; ActiveHealth Management

Submission details and entry form are available here. Deadline extended to February 19, 2010.  

View the 2009 Best Practices Awards compendium today.  

2010 Best Practices Categories
• Basic Research & Biological Research
• Drug Discovery & Development
• Clinical Trials & Research
• Translational Medicine
• Personalized Medicine
• IT & Informatics
• Knowledge Management
• Health-IT
• Manufacturing & Bioprocessing

If you have questions, write to  aproffitt@healthtech.com 

 
FEATURED CONTENT 

StorNext 4.0: Technical Product Brief   
Proven in the world's most data intensive industries, Quantum StorNext is a scalable, high-performance file system which allows data sharing across Linux, Mac, Unix, and Windows operating systems and manages data in enterprise storage environments. Download Whitepaper   (Sponsored by: Quantum )
 

The Key to Life Sciences Data  Management: Transparent Migration Life sciences organizations face new data management challenges as the volume of research data grows and more data is kept online for longer times.  Download Whitepaper (Sponsored by: BlueArc)


Protect Your Scientific Intellectual  Property: Proof of Lab Informatics Data Authenticity is Your Best Legal Defense
As a bio-technology or life sciences organization, your formulas, treatments and research and discoveries are the "lifeblood" of your business. But if you aren't protecting the integrity of your scientific data in your lab informatics systems, you risk losing IP ownership, revenue and consequently your business if you can't prove time-of-creation and data authenticity. Learn how you can implement simple, cost-effective and automated controls to protect your scientific intellectual property. Download Whitepaper (Sponsored by: Surety, LLC)

To have your white paper featured here, contact Lynn Cloonan for more information. 

 
EXCLUSIVE WEBCAST 

Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group
Life Science Webcasts 

New 
Moore's Law and the Future of Genome Sequencing
Guest: Jonathan Rothberg, Ph.D., Founder/CEO Ion Torrent Systems; Founder Curagen, 454 Life Sciences, Rain Dance
Editorial inteview conducted by Kevin Davies, Ph.D., Editor-in-Chief of Bio-IT World with Jonathan Rothberg reflecting on the past decade of his accomplishments and a glimpse at his new project, Ion Torrent Systems.  Interview conducted at CHI's Exploring Next Generation Sequencing conference in September 2009. 
 
Download Now 


New 
Oxford Nanopore's Third-Generation Sequencing Technology
Guest: John Milton, Ph.D., Vice President Research, Oxford Nanopore Technologies UK
Editorial interview conducted by Kevin Davies, Ph.D., Editor-in-Chief of Bio-IT World with John Milton that offers insights into Oxford Nanopore's potentially revolutionary new sequencing technology, which marries exonuclease cleavage of DNA and protein nanopores.  Interview conducted at CHI's Exploring Next Generation Sequencing conference in September 2009.
  Download Now

 
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We invite your comments and feedback for this edition of Weekly Update

Managing Editor
 
 

 Published by Cambridge Healthtech Media Group , division of CHI , Copyright Â© 2009; All rights reserved.  Bio-IT World Weekly Update may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
For reprints and/or copyright permission, please contact The YGS Group, 3650 West Market Street, York, PA 17404. Phone: 717-825-2150, ext. 125. Email:  ashley.zander@theYGSgroup.com