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CONFERENCE SERIES: Informatics & IT

Recorded at: Bio-IT World Conference & Expo

Digital Course: Pathway-Based Analysis: A Systematic Approach to Biomarker Discovery

Order DVD2011 BIT SC2 DVD About this Product: 

Historically, the study of molecular biology has tended toward reductionist, atomic views of complex systems. Recently, there has been a shift toward organizing our data and mindset around molecular pathways. In this digital course, we will focus on the utility of molecular pathways as an organizing principle for biomarker discovery. We will present several use case studies to illustrate how molecular pathways can be used to discover different types of biomarkers. We will then focus our discussion on the future of biomarker identification through the lens of pathway analysis.    

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About this Product: 

4 Presentations
110 Slides
Over 186 Minutes
Individual: $345
Site License: $1380 

 

 

Agenda At A Glance 

Introduction to Pathways and Systems BiologyLellean JeBailey 
Lellean JeBailey, Ph.D., Application Scientist, Thomson Reuters

Our introductory session will begin with brief history of systems biology from a physics perspective then transition to the concept of systems in biology. We will review cellular compartments and organization, as well as whole body tissue and highlight why and how a systems biology approach complements biologic function. Emphasis will be put on the role of a signaling pathway and how that is defined in systems biology language.  Some of the topics covered will be:

  • What is systems biology
  • Systems in the context of a cell, tissue, and whole organism
  • Who is a systems biologist

RAMP: A tool to search for clinically relevant imaging probes by disease pathways.Edward Khokhlovich 
Edward Khokhlovich, Scientific Technical Leader, Bioinformatics, Biomarker Development, Novartis Institutes for Biomedical Research, Cambridge, MA

Molecular imaging probes such as PET and SPECT tracers are used widely in clinical trials. Often investigators need an imaging probe for a particular disease pathway or cell phenotype. To help investigators find such probes, we've developed an application, consisting of a database and online search interface that enables scientists to systematically explore the relationships between an imaging probe, its respected target, and hundreds of biological pathways. We created the RAMP database that includes existing imaging probe data from Molecular Imaging and Contrast Database (MICAD) and several pathway databases from both public and commercial sources. In this talk we will provide an overview of the data structure behind the RAMP application, and will do a live demo of the application itself.

Imaging in drug discovery and development: from structure to function to molecules to pathwaysJeffrey Tsao 
Jeffrey Tsao, Ph.D., Associate Director, Oncology Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, MA
Imaging has evolved substantially over the past few decades. The improvement in technology has enabled a shift of focus from structural to functional to molecular assessment of diseases. This has been facilitated by the explosive development of imaging probes (non-specific, targeted, and activatable ones) as well as genetic constructs of reporters that enable pathway assessment in preclinical models. Despite the potential, the majority of these advanced imaging tools are not in clinical routine; they have mostly stayed at the proof of concept stage; and they seldom play a decision-critical role in drug development. Several components are needed to fuel the maturation of these tools towards practical routine use. They include, among others, 1. the ability to rigorously validate imaging probes and their robustness in application, 2. the ability to associate available imaging probes with disease processes and pathways.

In this talk, we will provide an overview that shows the changing roles of imaging, the successes, and the promises of advanced imaging techniques, including molecular imaging. We will then outline hurdles that have slowed down the adoption of advanced imaging tools in clinical routine, and approaches that are being pursued to overcome these challenges.

Methodologies for Biomarker Discovery, with and without Systems Biology ApproachesLellean JeBailey 
Lellean JeBailey, Ph.D., Application Scientist, Thomson Reuters
Our final session will provide a review of how biomarker discovery has traditionally been approached, how systems biology tools can facilitate this process now, and where they are taking biomarker discovery in the future. We will highlight the challenges of current approaches and how manually curated databases contribute to enhancing the biomarker trial. In addition, issues such as standardizing high throughput approaches, and how to approach biomarker discovery for multi-factorial diseases will be discussed.

BONUS FOOTAGE:

 

This digital course provides special footage of all Bio-IT Keynote Sessions. The Tuesday and Wednesday Keynote presentations offered vivid examples of the current and future impact of technology in data for research and drug discovery opportunities. Also included as part of the Wednesday Keynote material is The Benjamin Franklin Award presentation. The Benjamin Franklin Award is given to an individual who has, in his or her practice, promoted free and open access to the materials and methods used in the life sciences. The Thursday Keynote panel featured a series of succinct, forward looking presentations. Special guest speakers shared their unique perspective on the future challenges facing the research, pharma, and medical communities.

Tuesday 

StephenWolfram Sponsored by
Isilon
Making the World’s Knowledge Computable

Stephen Wolfram, Ph.D., CEO, Wolfram Research; Creator of Wolfram\Alpha 

 

 

Wednesday 

Bryn Roberts Sponsored by
Tessella
Interacting with Complex Information Landscapes: Integration and Next Generation User Interfaces

Bryn Roberts, Ph.D., Global Head, Informatics, Pharma Research and Early Development, F. Hoffmann-La Roche 

 

 

Jonathan Eisen Benjamin Franklin Award & Presentation
Jonathan Eisen, Ph.D., Professor, Genome Center, University of California, Davis 

 


 

Thursday 

Kevin Davies Sponsored by
BT small
Keynote Panel Chairperson

Kevin Davies, Editor-in-Chief, Bio-IT World 

 

 

Yuri Rozenman Pharma Futurology: 2016 and Beyond
Yury Rozenman, Global Head of Marketing, Pharmaceutical and Life Sciences Sector, BT Global Sciences 

 

 

Debra Goldfarb Global Risk Informatics: The Application of High Performance Computing to Public Health
Debra Goldfarb, Senior Director, Strategy, Microsoft 

 

 

Ken Buetow Ecosystem-Driven Approaches for 21st Century Biomedicine
Ken Buetow, Ph.D., Associate Director for Bioinformatics and Information Technology, National Cancer Institute 

 

 

Ben Heywood Integration of Real Time Discovery and Clinical Care
Ben Heywood, Co-founder and Chairman, PatientsLikeMe 

 

 

Mark Boguski The Goody-Gaga Effect: Health Communication at the Nexus of Social Media and Popular Culture
Mark Boguski, M.D., Ph.D., Founder, Resounding Health Incorporated 

 

 

Martin Leach Gaming in the Workplace
Martin D. Leach, Ph.D., Executive Director, MRL IT for Discovery & Pre-Clinical Sciences, Merck & Co. 

 

About the Conference:
Bio-IT World Conference & Expo
Enabling Technology.  Leveraging Data.  Transforming Medicine.
 

Since its debut in 2002, the annual Bio-IT World Conference & Expo (www.bio-itworldexpo.com) has established itself as a premier event showcasing the myriad applications of IT and informatics to biomedical research and the drug discovery enterprise. The Conference attracts a highly influential audience consisting of senior level scientists, IT professionals and Executives from organizations across the life sciences industry including Pharmaceutical, Biotechnology, Health Systems, Academia, Government and National Laboratories. In 2011, over 2,000 delegates gathered from 29 countries to share information and discuss enabling technologies that are driving the drug discovery process and transforming medicine. The event features concurrent tracks with 160+ technology and scientific presentations.

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Complimentary Downloads

View white papers, listen to podcasts, and more! 

  • Making the World's Knowledge Computable
  • Bioinformatics in the Cloud
  • The Application of Text Analytics to Drug Safety Surveillance
 

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